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Translational Medicine / 转化医学Endometrial Cancer TCGA, Molecular Classification

Douglas Levine

MD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Chief, Gynecology Service

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Key Contributions

👥Biography 个人简介

Douglas Levine at MSK co-led the TCGA (The Cancer Genome Atlas) molecular characterization of endometrial cancer — establishing four molecular subtypes: POLE ultramutated (excellent prognosis), microsatellite instability high/hypermutated, copy number low, and copy number high/serous-like (poor prognosis). This molecular classification has been incorporated into the revised 2023 FIGO staging for endometrial cancer and is transforming treatment stratification.

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🧪Research Fields 研究领域

endometrial cancer TCGA molecular
POLE-mutant endometrial cancer
copy number high serous-like endometrial
endometrial cancer molecular FIGO 2023
POLE POLEmut ultramutated

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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