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Translational Medicine / 转化医学Hallmarks of Cancer, Tumor Microenvironment

Douglas Hanahan

PhD

🏢Swiss Federal Institute of Technology Lausanne (EPFL)🌐Switzerland

Distinguished Scholar, Ludwig Institute for Cancer Research

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👥Biography 个人简介

Douglas Hanahan co-authored the Hallmarks of Cancer, the most influential conceptual framework in cancer biology, defining the organizing principles of cancer development. His expanded hallmarks papers (2011, 2022) incorporated emerging features including immune evasion, cellular plasticity, and senescent cells. His RIP-Tag transgenic mouse model has been instrumental in studying angiogenic switching and multi-step tumorigenesis.

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🧪Research Fields 研究领域

hallmarks of cancer framework
angiogenic switch
tumor microenvironment
RIP-Tag transgenic model
phenotypic plasticity cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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