Douglas Green

Douglas Green is a leading authority on the BCL-2 family of apoptosis regulators and their roles in cancer biology. He characterized how anti-apoptotic BCL-2 family members like BCL-XL and MCL-1 protect cancer cells from therapy-induced cell death. His work on the relationship between autophagy and apoptosis revealed dual roles in cancer cell survival and death. He has contributed substantially to understanding how cancer cells develop resistance to chemotherapy through apoptosis pathway disruption.