Domenico Ribatti

Domenico Ribatti has been a prolific researcher on the role of mast cells in tumor angiogenesis, demonstrating that mast cell-derived tryptase, VEGF, and FGF-2 are potent pro-angiogenic factors that drive tumor vascularization across multiple cancer types. His work established correlations between mast cell density and microvessel density in hematologic and solid malignancies. He has contributed to understanding how mast cells colonize the tumor microenvironment and promote the angiogenic switch. His extensive body of work has defined mast cells as key regulators of tumor angiogenesis.