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Translational Medicine / 转化医学Bone Marrow Failure and Cancer Predisposition

Inderjeet Dokal

MD, PhD, FRCP

🏢Barts and The London School of Medicine, Queen Mary University🌐UK

Professor of Paediatric Haematology

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Key Contributions

👥Biography 个人简介

Inderjeet Dokal has been a world leader in dyskeratosis congenita research, discovering multiple causative genes and establishing telomere length measurement as a diagnostic tool for telomere biology disorders. His work connecting telomere maintenance defects to cancer predisposition has revealed how short telomeres paradoxically increase cancer risk through genomic instability and selection for telomere maintenance-independent survival pathways. He has defined the clinical spectrum and cancer surveillance requirements for patients with telomere biology disorders.

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🧪Research Fields 研究领域

Dyskeratosis congenita
Telomere maintenance disorders
Telomerase biology
TINF2 mutations
Inherited cancer susceptibility

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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