Dmitriy Zamarin
德米特里·扎马林
MD, PhD
Associate Member, Human Oncology and Pathogenesis Program; Attending Physician, Gynecologic Medical Oncology人类肿瘤学与发病机制项目副研究员；妇科肿瘤内科主治医师
👥Biography 个人简介
Translational oncologist pioneering oncolytic virus-based intratumoral immunotherapy to overcome checkpoint resistance. His Newcastle disease virus (NDV) platform converts immunologically cold tumors into inflamed tumors, enabling synergy with systemic PD-1/CTLA-4 blockade in otherwise resistant cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Newcastle Disease Virus Oncolytic Platform
Developed recombinant NDV as an intratumoral immunotherapy agent, demonstrating its ability to induce immunogenic tumor cell death, recruit T cells, and sensitize resistant tumors to PD-1 and CTLA-4 checkpoint inhibitors.
Intratumoral-Systemic Combination Therapy
Established preclinical and clinical proof-of-concept that intratumoral NDV injection combined with systemic checkpoint blockade induces abscopal responses at distant, untreated lesions in mice and cancer patients.
Immune Evasion in Gynecologic Cancers
Characterized immune exclusion mechanisms in ovarian and endometrial cancers, providing the scientific foundation for clinical trials of combination oncolytic virus and checkpoint immunotherapy in gynecologic malignancies.
Representative Works 代表性著作
Localized Immunotherapy via Multilamellar Lipid Vesicles that Engage Local and Systemic Antitumour Immunity
Nature Biomedical Engineering (2020)
Described a lipid vesicle delivery platform for intratumoral immunotherapy, demonstrating local and abscopal anti-tumor immune responses.
Combination of Intratumoral Newcastle Disease Virus with Anti-CTLA-4 Generates Systemic Antitumour Immunity
Cancer Immunology Research (2014)
Demonstrated that intratumoral NDV converts immunologically cold tumors and, combined with CTLA-4 blockade, drives systemic anti-tumor immunity at distant sites.
Antitumor Effects of Oncolytic Influenza Virus in Immunotherapy-Resistant Tumors
Science Translational Medicine (2021)
Showed that engineered oncolytic influenza virus reprograms the immunosuppressive TME and restores responsiveness to checkpoint blockade.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 德米特里·扎马林 的研究动态
Follow Dmitriy Zamarin's research updates
留下邮箱，当我们发布与 Dmitriy Zamarin（Memorial Sloan Kettering Cancer Center）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment