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Translational Medicine / 转化医学ERV Cancer Immunology, Viral Mimicry

Dixie Mager

PhD

🏢University of British Columbia / BC Cancer Research Centre🌐Canada

Professor Emeritus, Department of Medical Genetics

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Key Contributions

👥Biography 个人简介

Dixie Mager has been a pioneer in understanding endogenous retroviruses (ERVs) and their role in cancer immunology. Her work demonstrated that ERV reactivation by epigenetic therapies triggers innate immune signaling through viral mimicry, providing a mechanistic rationale for combining demethylating agents with immunotherapy. She has mapped the expression landscape of human ERVs across normal and cancer tissues.

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🧪Research Fields 研究领域

endogenous retrovirus cancer
HERV expression
ERV immune response
epigenetic therapy ERV
viral mimicry innate immunity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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