Diane Simeone
黛安·西梅奥内
MD
Director, Pancreatic Cancer Center; Professor of Surgery胰腺癌中心主任；外科学教授
👥Biography 个人简介
Dr. Diane Simeone is a leading pancreatic cancer surgeon-scientist at NYU Langone. She directs research on early detection biomarkers, BRCA1/2-associated PDAC, and chemoprevention strategies. Her lab investigates metabolic reprogramming and immune evasion mechanisms in pancreatic ductal adenocarcinoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Early Detection
Developed multi-analyte blood-based biomarker panels for PDAC detection at resectable stages, advancing high-risk surveillance protocols for BRCA carriers and familial pancreatic cancer kindreds.
BRCA-PDAC Biology
Characterized DNA damage repair deficiencies in BRCA-mutant PDAC, supporting PARP inhibitor use and platinum-based regimens in hereditary pancreatic cancer patients.
Representative Works 代表性著作
Metabolic reprogramming as a driver of PDAC progression and therapy resistance
Cancer Cell (2023)
Identified glutamine and lipid metabolic vulnerabilities in PDAC with therapeutic implications.
Surveillance outcomes in high-risk individuals with familial pancreatic cancer
Journal of Clinical Oncology (2022)
Demonstrated improved resectability rates through structured high-risk PDAC surveillance programs.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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