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Translational Medicine / 转化医学Premenopausal HR+ Breast Cancer, Ovarian Suppression

Diana Bhatt

MD

🏢University of California San Francisco Helen Diller Family Comprehensive Cancer Center🌐USA

Assistant Professor of Breast Oncology

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👥Biography 个人简介

Diana Bhatt specializes in the management of premenopausal women with hormone receptor-positive breast cancer, examining optimal endocrine strategies combining ovarian function suppression with aromatase inhibitors or tamoxifen. Her research has contributed to translating SOFT and TEXT trial findings into clinical practice, identifying which premenopausal women benefit from ovarian suppression plus aromatase inhibitor versus tamoxifen alone based on clinical and genomic risk factors. She has studied fertility preservation strategies for premenopausal women with HR+ breast cancer who wish to conceive after completing treatment, and the oncologic safety of temporary treatment interruption for fertility in low-risk cases. Her clinical research addresses the unique challenges of managing early breast cancer in young women while balancing treatment intensity, toxicity, and quality of life.

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🧪Research Fields 研究领域

premenopausal HR+ breast cancer
ovarian function suppression OFS
tamoxifen aromatase inhibitor premenopausal
SOFT TEXT trial premenopausal breast
fertility preservation breast cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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