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Translational Medicine / 转化医学HER2 Discovery, Trastuzumab Development

Dennis Slamon

MD PhD

🏢UCLA🌐USA

Chief, Hematology-Oncology

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Key Contributions

👥Biography 个人简介

Dennis Slamon at UCLA identified HER2 amplification as an oncogene in breast cancer and championed the development of trastuzumab (Herceptin) against medical and industry skepticism. His persistence in developing trastuzumab for HER2-positive breast cancer transformed outcomes for the 20-25% of breast cancer patients with HER2 amplification — from among the worst prognosis to among the best when treated with HER2-targeted therapy. Slamon is a founding figure of modern precision oncology.

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🧪Research Fields 研究领域

HER2 amplification breast cancer discovery
trastuzumab herceptin development
HER2 breast cancer targeted therapy
HERA adjuvant trastuzumab trial
precision oncology HER2 breast pioneer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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