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Translational Medicine / 转化医学HER2 Targeted Therapy, Translational Oncology

Dennis Slamon

MD, PhD

🏢University of California, Los Angeles🌐USA

Director, Revlon/UCLA Women's Cancer Research Program

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Key Contributions

👥Biography 个人简介

Dennis Slamon discovered that HER2 amplification drives aggressive breast cancer and developed trastuzumab (Herceptin), the first oncogene-targeted therapy approved for solid tumors. His work demonstrated that molecular characterization of tumors could identify patients who benefit from targeted agents, establishing the paradigm of biomarker-driven cancer treatment. Trastuzumab has transformed HER2-positive breast cancer from the most deadly to one of the most treatable subtypes.

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🧪Research Fields 研究领域

HER2 discovery
trastuzumab development
targeted therapy breast cancer
oncogene-directed therapy
biomarker-driven treatment

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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