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Translational Medicine / 转化医学HR+ Breast, CDK4/6 Inhibitors

Dennis Slamon

MD, PhD

🏢UCLA Jonsson Comprehensive Cancer Center🌐USA

Director, Clinical/Translational Research, Jonsson Comprehensive Cancer Center

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Key Contributions

👥Biography 个人简介

Dennis Slamon at UCLA is internationally recognized for his discovery of HER2 amplification in breast cancer and development of trastuzumab, and has more recently contributed to CDK4/6 inhibitor development for HR-positive breast cancer. His translational research integrates molecular tumor profiling with targeted therapy development. He continues to investigate mechanisms of endocrine resistance and novel combination strategies.

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🧪Research Fields 研究领域

CDK4/6 inhibitors HR+ breast
palbociclib clinical development
HER2 trastuzumab discovery
breast cancer molecular
translational oncology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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