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Translational Medicine / 转化医学Cell-Free DNA, NIPT, NPC Screening

Dennis Lo

MBBChir DPhil

🏢Chinese University of Hong Kong🌐Hong Kong

Li Ka Shing Professor

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Key Papers
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Key Contributions

👥Biography 个人简介

Dennis Lo at CUHK discovered fetal cell-free DNA in maternal blood — the foundational finding that enabled non-invasive prenatal testing (NIPT). His subsequent work on cell-free DNA fragmentation patterns, nucleosome positioning, and EBV ctDNA-based screening for nasopharyngeal carcinoma has been foundational for liquid biopsy cancer diagnostics. His population-based NPC screening study using plasma EBV DNA demonstrated feasibility of blood-based cancer early detection.

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🧪Research Fields 研究领域

cell-free DNA discovery
fetal DNA blood
nasopharyngeal carcinoma EBV ctDNA
DNA fragmentation patterns
plasma DNA cancer diagnostics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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