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Translational Medicine / 转化医学HER3-low ADC, Patritumab Deruxtecan

Dejan Juric

MD

🏢Massachusetts General Hospital / Harvard Medical School🌐USA

Co-Director, Termeer Center for Targeted Therapies

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👥Biography 个人简介

Dejan Juric is a medical oncologist specializing in early-phase clinical trials in breast cancer, including first-in-human and expansion studies with patritumab deruxtecan (HER3-DXd, U3-1402), a next-generation ADC targeting HER3-low expression. His research has established HER3 as a broadly expressed and therapeutically actionable target in breast cancer regardless of HER2 status, complementing the HER2-low paradigm. He also leads research on PI3K pathway inhibitors and resistance mechanisms.

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🧪Research Fields 研究领域

patritumab deruxtecan HER3-low
HER3 expression breast cancer
U3-1402 clinical development
PI3K inhibitors breast cancer
early-phase oncology trials

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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