Dean Fennell
迪恩·芬内尔
PhD, FRCP
Professor of Thoracic Medical Oncology and Chair of Thoracic Oncology胸部肿瘤内科学教授兼胸部肿瘤学主席
👥Biography 个人简介
Dean Fennell leads mesothelioma research at the University of Leicester and is a principal investigator for the UK MesobanK tissue biobank. He focuses on molecular drivers of mesothelioma, BAP1 tumor suppressor biology, and novel therapeutic targeting, leading major UK and European clinical trials.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Molecular Pathogenesis
Elucidated the role of BAP1, NF2, and SETD2 mutations in mesothelioma oncogenesis, providing the molecular framework for targeted therapy development.
MesobanK Biobank
Co-founded and directs the UK MesobanK, the world's largest mesothelioma tissue biobank, enabling translational research and biomarker discovery at scale.
Novel Therapeutics
Led CONFIRM and RAMES trials of nivolumab and ramucirumab in relapsed mesothelioma, demonstrating clinically meaningful benefit and informing second-line treatment standards.
Representative Works 代表性著作
Nivolumab versus placebo in previously treated malignant pleural mesothelioma (CONFIRM)
Lancet Oncology (2021)
Phase III trial establishing nivolumab as the first immunotherapy with a significant overall survival benefit in relapsed mesothelioma.
Whole-exome sequencing of mesothelioma reveals frequent mutations in the BAP1 and NF2 genes
Nature Genetics (2011)
Landmark genomic analysis defining the mutational landscape of mesothelioma and identifying key therapeutic targets.
Navitoclax combined with pemetrexed and cisplatin in patients with advanced mesothelioma
Journal of Thoracic Oncology (2019)
Evaluated BCL-2/BCL-XL inhibition as a sensitization strategy, advancing translational apoptosis-targeted approaches in mesothelioma.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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