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Translational Medicine / 转化医学Senolytic Therapy Clinical Research

Peter de Keizer

PhD

🏢University Medical Center Utrecht🌐Netherlands

Associate Professor of Aging Biology

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👥Biography 个人简介

Peter de Keizer developed the FOXO4-DRI peptide, a targeted senolytic that disrupts the p53-FOXO4 interaction maintaining senescent cell viability, demonstrating proof of concept for protein-protein interaction-based senolytic strategies. His work shows that FOXO4-DRI selectively eliminates chemotherapy-induced senescent cells and restores tissue function in aged mice. He advances peptide-based senolytic therapeutics toward clinical development for cancer adjuvant therapy.

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🧪Research Fields 研究领域

FOXO4-DRI peptide senolytic
p53-FOXO4 interaction
Targeted senolytic peptides
Liver fibrosis and senescence
Chemotherapy-induced senescence

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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