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Translational Medicine / 转化医学Bifunctional Antibody Engineering

Jonathan Davis

PhD

🏢Genentech / Roche🌐USA

Vice President of Antibody Engineering

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👥Biography 个人简介

Jonathan Davis leads antibody engineering at Genentech, where he has developed novel bispecific and multispecific antibody formats including CrossMAb technology that enables correct heavy-light chain pairing in bispecific IgG antibodies. His work has produced clinically validated bispecific antibodies including glofitamab and mosunetuzumab for hematologic malignancies. He continues to advance next-generation multispecific formats that simultaneously engage multiple targets on tumor cells and immune effectors.

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🧪Research Fields 研究领域

Bispecific antibody design
CrossMAb technology
T cell-engaging bispecifics
Antibody structural engineering
Multispecific format innovation

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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