David Ziegler
大卫·齐格勒
MBBS, PhD, FRACP
Head, Brain Tumour Group; Associate Professor of Paediatric Oncology脑肿瘤研究组负责人；儿童肿瘤学副教授
👥Biography 个人简介
David Ziegler is Australia's foremost pediatric neuro-oncologist at Children's Cancer Institute Sydney, who co-led pivotal ONC201 trials in H3K27M DMG, established Australia's national DIPG clinical research program, and leads the Zero Childhood Cancer precision medicine program integrating whole-genome sequencing for every Australian child with a high-risk cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
ONC201 International Trial Leadership
Co-led international ONC201 (dordaviprone) trials in H3K27M DMG including the H3K27M cohort of DIPG studies supporting FDA approval, enrolling Australian and global patients.
Zero Childhood Cancer Program
Co-leads the Zero Childhood Cancer national precision medicine program providing whole-genome sequencing and molecular tumor boards for every Australian child with high-risk cancer.
Australia DIPG Research Network
Founded and leads the Australian DIPG Research Network coordinating multi-site clinical trials, biobanking, and compassionate access programs across all Australian pediatric oncology centers.
Representative Works 代表性著作
ONC201 in pediatric H3K27M-mutant diffuse midline glioma: the Australian experience
Neuro-Oncology (2023)
Australian cohort study of ONC201 in DMG demonstrating response rates consistent with global data and supporting drug access programs.
Whole-genome sequencing identifies actionable alterations in majority of pediatric high-risk cancers
Nature Medicine (2022)
Zero Childhood Cancer program results demonstrating whole-genome and transcriptome sequencing yields actionable findings in 72% of high-risk pediatric cancers.
DIPG treatment landscape 2025: from biology to bedside
Lancet Child & Adolescent Health (2024)
Comprehensive review of DIPG treatment advances including ONC201, CED, immunotherapy, and combinations, synthesizing the path to improved outcomes.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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留下邮箱，当我们发布与 David Ziegler（Children's Cancer Institute / Sydney Children's Hospital, UNSW Sydney）相关的新研究或访谈时，我们会通知你。
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