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Translational Medicine / 转化医学Cancer Pharmacology

David Weinstock

大卫·温斯托克

MD

🏢Dana-Farber Cancer Institute(达纳-法伯癌症研究所)🌐USA

Associate Professor of Medicine, Harvard Medical School哈佛医学院医学副教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Expert in oncology drug resistance in lymphoma and genomic mechanisms of cancer therapy failure. Investigates how genomic alterations in lymphoma drive resistance to targeted therapies and immunotherapy, with specific focus on DLBCL and follicular lymphoma resistance to BCL-2 inhibitors and PI3K pathway agents.

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🧪Research Fields 研究领域

Drug Resistance耐药机制
Cancer Pharmacology癌症药理学
Targeted Therapy靶向治疗

🎓Key Contributions 主要贡献

Lymphoma Drug Resistance and Genomics

Characterized genomic mechanisms of resistance to BCL-2 inhibitors and PI3K pathway inhibitors in aggressive B-cell lymphomas, identifying recurrent resistance mutations and defining rational co-targeting strategies to prevent and overcome resistance.

Representative Works 代表性著作

[1]

ATM mutations in the cancer genome

Cancer Cell (2010)

Defined the landscape of ATM mutations in lymphoma and other cancers, revealing ATM loss as a driver of genomic instability and therapeutic vulnerability.

🏆Awards & Recognition 奖项与荣誉

🏆American Society of Hematology Young Investigator Award
🏆Lymphoma Research Foundation Discovery Grant

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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