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Translational Medicine / 转化医学Synovial Sarcoma, Sarcoma Genomics

David Thomas

MBBS, PhD

🏢Garvan Institute of Medical Research🌐Australia

Professor and Director, Garvan-Weizmann Centre for Cellular Genomics

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👥Biography 个人简介

David Thomas is an internationally recognized leader in sarcoma genomics and personalized therapy, directing Australia's national sarcoma research program. His work on the molecular landscape of synovial sarcoma, including the SS18-SSX fusion and its epigenetic consequences, has informed the development of targeted therapies such as EZH2 inhibitors and NY-ESO-1-directed T cell therapies. He co-founded the International Sarcoma Kindred Study (ISKS) to identify inherited predisposition to sarcoma. His translational genomics approach has advanced precision oncology for rare sarcoma subtypes.

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🧪Research Fields 研究领域

synovial sarcoma SS18-SSX genomics
sarcoma precision oncology
NY-ESO-1 T cell therapy synovial sarcoma
SWI-SNF complex sarcoma
sarcoma cancer genomics Australia

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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