David Stout

David Stout is a structural biologist who has contributed to understanding the three-dimensional structures of protein kinases relevant to cancer targeted therapy. His crystallographic studies have revealed how kinase inhibitors bind their targets and the structural basis for selectivity and resistance mutations. High-resolution kinase structures from his laboratory and others in the field have been essential tools for rational drug design efforts yielding clinical oncology agents. His structural insights have informed lead optimization in drug discovery programs targeting oncogenic kinases and remain valuable resources for medicinal chemistry.