David L. Rimm
大卫·里姆
MD, PhD
Professor of Pathology and Director of Translational Pathology病理学教授兼转化病理学主任
👥Biography 个人简介
Pioneer in quantitative immunofluorescence (AQUA) for cancer biomarker measurement. Led landmark studies standardizing HER2 and PD-L1 IHC assays across platforms, advancing reproducibility and clinical utility of predictive biomarkers in solid tumors.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Quantitative IHC Standardization
Developed AQUA technology enabling objective, automated quantification of protein biomarkers in tumor tissue, fundamentally improving reproducibility of HER2 and PD-L1 testing across clinical laboratories.
PD-L1 Assay Harmonization
Led multi-platform studies revealing significant inter-assay variability in PD-L1 scoring, driving international efforts to harmonize PD-L1 companion diagnostic assays for immune checkpoint inhibitor selection.
Representative Works 代表性著作
Multiplexed Quantitative Immunofluorescence for PD-L1 Biomarker Assessment in Non-Small Cell Lung Cancer
Journal of Thoracic Oncology (2023)
Demonstrated superior reproducibility of quantitative immunofluorescence over standard IHC for PD-L1 scoring in NSCLC tissue microarrays.
Comparison of Four Antibody Clones for PD-L1 Testing in Non-Small Cell Lung Cancer
JAMA Oncology (2022)
Systematic comparison of PD-L1 assay platforms revealing concordance and discordance patterns critical for clinical decision-making.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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