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Translational Medicine / 转化医学Endometrial Cancer Biology, PARP Inhibitors, Epigenetics

David Matei

MD

🏢Northwestern University, Feinberg School of Medicine🌐USA

Professor and Division Director, Gynecologic Oncology

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👥Biography 个人简介

David Matei is a translational gynecologic oncologist whose research bridges endometrial cancer biology with novel therapeutic strategies. His work has addressed DNA repair deficiencies, epigenetic reprogramming by hypomethylating agents to enhance platinum sensitivity, and the role of HER2 in uterine serous carcinoma. He has led clinical trials investigating trastuzumab in HER2-amplified endometrial serous cancer and evaluated PARP inhibitor combinations. His basic and translational research program has identified novel molecular targets in endometrial cancer.

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🧪Research Fields 研究领域

endometrial cancer PARP inhibitors
platinum sensitivity endometrial cancer
DNA methylation endometrial cancer
HER2 endometrial cancer
epigenetic therapy endometrial

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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