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Translational Medicine / 转化医学Base Editing, Prime Editing, Cancer Mutation Correction

David Liu

PhD

🏢Harvard University / Broad Institute🌐USA

Professor, Harvard University; Core Member, Broad Institute

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👥Biography 个人简介

David Liu invented base editing, a technology that can make precise single-letter changes in DNA without double-strand breaks, and prime editing, which enables virtually any genetic change without double-strand cuts. These technologies have particular promise for correcting cancer-causing point mutations and engineering therapeutic cells. His laboratory continues to improve editing precision and delivery, and has generated multiple therapeutic programs entering clinical development. He is widely regarded as one of the most innovative scientists in the genome editing field.

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🧪Research Fields 研究领域

base editing
prime editing
directed evolution
cancer mutation correction
gene therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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