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Translational Medicine / 转化医学Vaccinia Virus Oncolytic, Pexastimogene

David Kirn

MD

🏢Jennerex / SillaJen🌐USA

Co-Founder and CSO

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Key Contributions

👥Biography 个人简介

David Kirn co-developed pexastimogene devacirepvec (JX-594, Pexa-Vec) — a GM-CSF-expressing oncolytic vaccinia virus — including clinical development demonstrating objective responses and survival benefit signals in advanced hepatocellular carcinoma. His foundational work on optimizing oncolytic viruses for therapeutic activity and his clinical development programs contributed to advancing vaccinia-based oncolytic therapy.

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🧪Research Fields 研究领域

pexastimogene devacirepvec JX-594
vaccinia oncolytic virus HCC
oncolytic poxvirus cancer
GM-CSF expressing oncolytic virus
hepatocellular carcinoma oncolytic

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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