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Translational Medicine / 转化医学Molecular Tumor Board, Tumor-Agnostic Therapy

David Hyman

MD

🏢Loxo Oncology at Lilly🌐USA

Chief Medical Officer

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👥Biography 个人简介

Dr. David Hyman is a clinical oncologist and drug developer who led the clinical development of larotrectinib, the first tumor-agnostic FDA-approved cancer therapy targeting NTRK fusions. He pioneered basket trial design principles for histology-independent oncology drug development and has contributed to regulatory frameworks for tumor-agnostic approvals. His work fundamentally changed how oncology drugs can be developed and approved beyond single cancer types.

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🧪Research Fields 研究领域

tumor-agnostic FDA approvals
NTRK TRK inhibitor larotrectinib
BRAF tumor agnostic dabrafenib trametinib
histology-independent drug development
basket trial signal finding

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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