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Translational Medicine / 转化医学Basket Trials, TRK Inhibitors

David Hyman

MD

🏢Relay Therapeutics🌐USA

Chief Medical Officer

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Key Contributions

👥Biography 个人简介

David Hyman pioneered basket trial methodology at Memorial Sloan Kettering and led the pivotal larotrectinib trials that resulted in the first tumor-agnostic FDA approval based on a molecular alteration. He has been a key figure in developing the regulatory and clinical framework for biomarker-selected, histology-independent drug approvals. His work spans TRK, RET, and other fusion oncoproteins.

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🧪Research Fields 研究领域

basket trials
NTRK inhibitors
tumor-agnostic approvals
precision oncology
early drug development

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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