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Translational Medicine / 转化医学Basket Trials Tumor-Agnostic

David Hyman

MD

🏢Memorial Sloan Kettering Cancer Center and Loxo Oncology🌐USA

Former Chief of Early Drug Development

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Key Contributions

👥Biography 个人简介

David Hyman pioneered tumor-agnostic basket trials including the landmark vemurafenib BRAF and larotrectinib NTRK studies that established tissue-agnostic FDA approvals as a new regulatory paradigm. His methodological work transformed drug development around molecular rather than histologic classification. He shaped the modern framework for basket trial design and interpretation.

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🧪Research Fields 研究领域

basket trial design pioneer
larotrectinib NTRK tumor-agnostic
vemurafenib BRAF histology-independent
tissue-agnostic development
precision oncology trial methodology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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