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Translational Medicine / 转化医学WNT Signaling, Pancreatic Cancer

David Bhatt

MD

🏢Johns Hopkins Hospital🌐USA

Associate Professor of Surgical Oncology

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Key Contributions

👥Biography 个人简介

David Bhatt examines crosstalk between WNT signaling and KRAS oncogenic pathways in pancreatic ductal adenocarcinoma. His research has shown that WNT pathway activation modulates stromal remodeling and immune exclusion in pancreatic tumors. He has identified context-dependent roles of WNT signaling in different stages of pancreatic cancer progression. His work is guiding combination strategies targeting both KRAS and WNT in this recalcitrant malignancy.

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🧪Research Fields 研究领域

pancreatic cancer
WNT pathway
KRAS interactions
tumor microenvironment
cancer biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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