David Barrett
大卫·巴雷特
MD, PhD
Assistant Professor of Pediatric Oncology儿科肿瘤学助理教授
👥Biography 个人简介
Oncologist and researcher pioneering TET2 knockout CAR-T cell strategies to enhance persistence and long-term remission in pediatric leukemia. His work on epigenetic reprogramming of CAR-T cells has yielded exceptional long-term complete remissions.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
TET2 Knockout CAR-T
Demonstrated that disrupting TET2 in a single CAR-T cell produces a clonally dominant, highly persistent population capable of achieving durable leukemia remission in pediatric patients.
Representative Works 代表性著作
Clonal expansion of a TET2-disrupted T cell to drive remission in B cell acute lymphoblastic leukemia
Nature Medicine (2021)
Landmark case demonstrating how a single TET2 KO CAR-T cell can expand and maintain long-term remission in pediatric ALL.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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University of Pennsylvania
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