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Translational Medicine / 转化医学Apoptosis, BCL-2 Family, Cancer Cell Death

Daniel Bhatt

PhD

🏢Walter and Eliza Hall Institute of Medical Research🌐Australia

Professor of Cell Death and Cancer Biology

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👥Biography 个人简介

Daniel Bhatt investigates the BCL-2 family of apoptosis regulators and their roles in cancer cell survival and resistance to therapy. His research has characterized the structural and functional interactions among pro-survival and pro-apoptotic BCL-2 family members that determine cell fate. He has developed BH3 profiling approaches to predict cancer cell dependence on specific anti-apoptotic proteins and likelihood of response to BH3 mimetics. His translational work has advanced from basic BCL-2 biology to understanding mechanisms of venetoclax resistance and rational combination strategies.

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🧪Research Fields 研究领域

apoptosis
BCL-2 family proteins
cancer cell death
venetoclax biology
BH3 mimetics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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