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Translational Medicine / 转化医学Clonal Evolution Under Therapy

Christina Curtis

PhD

🏢Stanford University🌐USA

Professor of Medicine and Genetics

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👥Biography 个人简介

Christina Curtis has developed computational approaches to reconstruct the evolutionary histories of breast and colorectal cancers, creating the integrative molecular classification system that reveals how evolutionary trajectories determine clinical outcomes and treatment response. Her laboratory at Stanford has demonstrated that the timing and order of driver mutations during tumor evolution predicts metastatic potential and therapy resistance patterns. Her work integrates computational modeling with genomic data to create predictive evolutionary frameworks for precision oncology.

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🧪Research Fields 研究领域

Breast cancer evolutionary subtypes
Clonal dynamics modeling
Computational tumor phylogenetics
IntClust molecular classification
Treatment resistance evolution

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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