Constantine Stratakis

Constantine Stratakis has characterized multiple hereditary syndromes predisposing to adrenocortical tumors, including Carney complex caused by PRKAR1A mutations and McCune-Albright syndrome involving GNAS, and has elucidated cAMP signaling pathway dysregulation as a central mechanism in adrenal tumor formation. His work connecting these rare germline syndromes to ACC has improved genetic counseling and surveillance for at-risk families. He has also studied the high prevalence of TP53 germline mutations in pediatric ACC in Brazil, representing a distinct geographic and biological entity.