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Translational Medicine / 转化医学Tumor Organoid Drug Screening

Hans Clevers

MD, PhD

🏢Roche🌐Netherlands

Head of Pharma Research and Early Development

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Key Contributions

👥Biography 个人简介

Hans Clevers is the inventor of organoid technology, having discovered Lgr5+ intestinal stem cells and developed culture conditions that allow indefinite propagation of patient-derived tumor organoids for drug screening. His organoid biobanks spanning dozens of cancer types have enabled large-scale pharmacotyping studies that predict individual patient responses to chemotherapy. He has transformed cancer drug development from cell line-based to patient-representative model systems.

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🧪Research Fields 研究领域

Organoid technology
Wnt signaling and stem cells
Lgr5 intestinal stem cells
Patient-derived organoids
Organoid biobanking

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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