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Translational Medicine / 转化医学TERRA lncRNA, Telomere Regulation

Claus Azzalin

PhD

🏢Instituto de Medicina Molecular, University of Lisbon🌐Portugal

Principal Investigator

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Key Papers
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Key Contributions

👥Biography 个人简介

Claus Azzalin discovered TERRA (telomeric repeat-containing RNA), the long non-coding RNA transcribed from telomeres that plays critical roles in telomere maintenance and ALT pathway activation. His work showed that TERRA forms R-loops at telomeres, promoting recombination-based telomere lengthening in ALT-positive cancers. He has revealed how TERRA regulates telomere heterochromatin and the DNA damage response at chromosome ends.

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🧪Research Fields 研究领域

TERRA lncRNA telomere
telomeric repeat RNA
R-loops telomeres
ALT TERRA
telomere transcription

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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