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Translational Medicine / 转化医学Gut-Brain Axis in Cancer

Gerard Clarke

PhD

🏢University College Cork🌐Ireland

Professor of Psychiatry and Neurobehavioural Science

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Key Contributions

👥Biography 个人简介

Gerard Clarke investigates how gut microbial manipulation of tryptophan metabolism through the kynurenine pathway influences both cancer immune evasion and cancer-related cognitive impairment. His metabolomic studies have identified microbial-derived tryptophan catabolites that suppress anti-tumor immunity while promoting neuroinflammation. His work connects immunotherapy response biomarkers with gut-brain axis metabolites in cancer patients.

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🧪Research Fields 研究领域

Tryptophan metabolism
Serotonin and gut microbiome
Kynurenine pathway in cancer
Microbiome and chemobrain
Metabolomics of gut-brain axis

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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