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Translational Medicine / 转化医学mSWI/SNF Chromatin Remodeling, Cancer

Cigall Kadoch

MD

🏢Dana-Farber Cancer Institute / Harvard Medical School🌐USA

Professor

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Key Contributions

👥Biography 个人简介

Cigall Kadoch at Dana-Farber is a world authority on the mSWI/SNF chromatin remodeling complex family and their roles in cancer. Her landmark work on synovial sarcoma, demonstrating that SS18-SSX fusion proteins incorporate into and subvert mBAF complexes to drive oncogenesis, has transformed understanding of this disease. Her comprehensive characterization of ARID1A, SMARCA4, and other mSWI/SNF subunit mutations across many cancer types has identified epigenetic vulnerabilities being therapeutically targeted.

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🧪Research Fields 研究领域

mSWI/SNF chromatin remodeling
SMARCB1 INI1
synovial sarcoma SS18-SSX
ARID1A mutations
chromatin remodeling complexes cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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