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Translational Medicine / 转化医学m6A RNA Methylation, RNA Epitranscriptomics

Chuan He

PhD

🏢University of Chicago🌐USA

John T. Wilson Distinguished Service Professor

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Key Contributions

👥Biography 个人简介

Chuan He at Chicago pioneered the field of RNA epitranscriptomics by discovering that m6A (N6-methyladenosine) — the most abundant internal mRNA modification — is a dynamic and reversible mark regulated by writer (METTL3/METTL14), eraser (FTO/ALKBH5), and reader proteins. His work demonstrating dysregulation of m6A methylation in cancer and the therapeutic potential of targeting m6A writers and erasers has opened a new layer of RNA-based cancer regulation.

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🧪Research Fields 研究领域

m6A RNA methylation cancer
N6-methyladenosine
RNA epitranscriptomics
FTO METTL3 cancer
RNA methylation reader eraser writer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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