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Translational Medicine / 转化医学m6A RNA Modification, Epitranscriptomics

Chuan He

PhD

🏢University of Chicago🌐USA

John T. Wilson Distinguished Service Professor of Chemistry

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Key Contributions

👥Biography 个人简介

Chuan He is a founder of the RNA epitranscriptomics field, having discovered that m6A methylation on mRNA is reversible through the FTO and ALKBH5 demethylases. His work established that dynamic RNA modifications regulate gene expression in cancer, with FTO acting as an oncogene in acute myeloid leukemia and glioblastoma. He continues to expand the catalog of functional RNA modifications with implications for cancer biology and therapeutics.

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🧪Research Fields 研究领域

m6A RNA modification
epitranscriptomics
FTO demethylase
RNA epigenetics
chemical biology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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