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Translational Medicine / 转化医学HER2-low Biomarkers, Breast Cancer Genomics

Christos Sotiriou

MD, PhD

🏢Institut Jules Bordet / Universite Libre de Bruxelles🌐Belgium

Head, Breast Cancer Translational Research Laboratory

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Key Contributions

👥Biography 个人简介

Christos Sotiriou is a preeminent breast cancer translational researcher who has investigated the molecular landscape of HER2-low tumors, including gene expression profiling to understand whether HER2-low constitutes a biologically distinct entity. His group has analyzed intrinsic subtypes within HER2-low cancers and explored how luminal B and triple-negative HER2-low cancers differ in their biology and T-DXd response. He is a founding figure in transcriptomic profiling of breast cancer and leads the TRANSBIG research consortium.

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🧪Research Fields 研究领域

HER2 IHC 1+ 2+ ISH- biomarkers
breast cancer genomic subtypes
HER2-low heterogeneity transcriptomics
luminal B HER2-low molecular features
predictive biomarker discovery

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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