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Translational Medicine / 转化医学BET Bromodomain Inhibitors, MYC Oncology

Christopher Bhatt

PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Senior Scientist

22
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Key Papers
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Key Contributions

👥Biography 个人简介

Christopher Bhatt is a cancer epigenomics researcher at Memorial Sloan Kettering focusing on BET bromodomain inhibitors and their mechanisms of action in MYC-driven cancers. His research investigated how BRD4 and other BET proteins regulate super-enhancers that drive oncogene expression, particularly MYC amplification in multiple myeloma and lymphoma. He contributed to elucidating resistance mechanisms to BET inhibitors and developing combination strategies to overcome them. His work has informed next-generation BET inhibitor development for hematologic malignancies.

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🧪Research Fields 研究领域

BET bromodomain inhibitors
BRD4 cancer
JQ1 mechanism
MYC transcriptional regulation
super-enhancer targeting cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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