Chiara Bonini
基娅拉·博尼尼
MD
Professor of Hematology and Head of Experimental Hematology Unit血液学教授及实验血液学部门负责人
👥Biography 个人简介
Internationally recognized expert in T-cell gene therapy safety and suicide gene systems. Pioneered clinical application of herpes simplex virus thymidine kinase (HSV-TK) suicide gene in donor lymphocyte infusion and CAR-T cells to enable controlled elimination of therapeutic T cells.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Suicide Gene Safety in T-Cell Therapy
Developed and clinically validated HSV-TK suicide gene strategies to safely terminate CAR-T activity in cases of toxicity, establishing a key safety framework for engineered T-cell therapies.
Representative Works 代表性著作
Modified T cells with a suicide gene for the treatment of graft-versus-host disease
New England Journal of Medicine (2005)
Landmark trial demonstrating HSV-TK suicide gene T-cell safety and efficacy in controlling GvHD after allogeneic transplant.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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