Charlie Gourley
查理·古尔利
PhD, FRCP
Professor of Medical Oncology; Director, Nicola Murray Centre for Ovarian Cancer Research肿瘤内科学教授；尼古拉·默里卵巢癌研究中心主任
👥Biography 个人简介
Charlie Gourley, PhD, FRCP is a Professor of Medical Oncology at the University of Edinburgh and Director of the Nicola Murray Centre for Ovarian Cancer Research. He is internationally recognized for pioneering the concept of 'BRCAness' — the functional HRD phenotype beyond BRCA mutation — and for investigating PARP inhibitor response mechanisms in ovarian cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
BRCAness and Homologous Recombination Deficiency in Ovarian Cancer
Pioneered clinical research into BRCAness as a functional HRD phenotype predicting PARP inhibitor sensitivity beyond germline BRCA mutation, reshaping patient selection strategies for PARP inhibitor therapy.
Mechanisms of PARP Inhibitor Response and Resistance
Led translational studies dissecting mechanisms of PARP inhibitor sensitivity and acquired resistance in high-grade serous ovarian cancer, informing combination strategies to overcome resistance.
Representative Works 代表性著作
Olaparib versus placebo in patients with BRCA1 or BRCA2 mutations and recurrent high-grade serous ovarian carcinoma (Study 19 translational analysis)
The Lancet Oncology (2014)
Translational analysis of BRCAness biomarkers from Study 19, demonstrating that HRD phenotype beyond germline BRCA mutation can predict olaparib benefit.
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1)
The Lancet Oncology (2017)
Defined genomic scar HRD score as a predictive biomarker for rucaparib activity, establishing HRD-based patient selection beyond BRCA mutation status.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 查理·古尔利 的研究动态
Follow Charlie Gourley's research updates
留下邮箱，当我们发布与 Charlie Gourley（University of Edinburgh / Edinburgh Cancer Research Centre）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment