Charles Sherr
MD PhD
Investigator
👥Biography 个人简介
Charles Sherr at St. Jude is a cell cycle pioneer who made fundamental contributions to understanding the CDK4/6-cyclin D-RB pathway that controls the G1/S transition. His discovery of CDK4, characterization of INK4 family CDK inhibitors (p16INK4a), and elucidation of how this pathway is disrupted in virtually all cancers provided the molecular basis for CDK4/6 inhibitor drugs (palbociclib, ribociclib, abemaciclib) — now standard of care in breast cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-02-01 | All information from publicly available academic sources
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