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Translational Medicine / 转化医学Leukemia, ALL Genomics

Charles Mullighan

MBBS(Hons), MSc, MD

🏢St. Jude Children's Research Hospital🌐USA

Member, Department of Pathology

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Key Contributions

👥Biography 个人简介

Charles Mullighan has transformed the genomic understanding of acute lymphoblastic leukemia through comprehensive sequencing studies. He described the Ph-like (BCR-ABL1-like) ALL subtype, which affects a large proportion of high-risk patients and has actionable kinase alterations. His work on CRLF2 overexpression and IKZF1 deletions has refined risk stratification in pediatric and adult ALL. He leads major genomic classification efforts for ALL worldwide.

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🧪Research Fields 研究领域

ALL genomic classification
Ph-like ALL
CRLF2 ALL
pediatric ALL molecular drivers
BCR-ABL1-like ALL

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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