Charles Loprinzi
查尔斯·洛普林齐
MD
Regis Professor of Breast Cancer Research, Department of Oncology肿瘤科乳腺癌研究Regis讲席教授
👥Biography 个人简介
Charles Loprinzi is a preeminent Mayo Clinic oncologist and clinical trialist who has shaped supportive oncology through landmark trials on cancer-related weight loss, appetite stimulation with megestrol acetate, and symptom management. His work on megestrol and weight gain established a foundational pharmacological approach to cancer cachexia.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Megestrol Acetate for Cancer Cachexia
Conducted pivotal randomized trials establishing megestrol acetate as an effective appetite stimulant and weight-gain agent in cancer cachexia, leading directly to FDA approval for this indication.
Dose Optimization of Appetite Stimulants
Performed dose-response trials of megestrol acetate defining optimal dosing for weight gain while minimizing toxicity, directly informing clinical prescribing guidelines.
Comprehensive Cancer Symptom Research
Led NCCTG cooperative group trials across a broad portfolio of cancer supportive care including fatigue, hot flashes, neuropathy, and anorexia, establishing an evidence base for symptom control.
Representative Works 代表性著作
Megestrol acetate for the prevention of hot flashes
New England Journal of Medicine (1994)
Randomized trial demonstrating megestrol acetate efficacy for cancer-related hot flashes, expanding the drug's supportive care applications beyond appetite stimulation.
Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia
Journal of Clinical Oncology (1999)
Three-arm trial establishing megestrol acetate superiority for weight gain and appetite in cancer cachexia, with direct impact on supportive care guidelines.
Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trial
The Lancet (2000)
Landmark trial demonstrating venlafaxine efficacy for hot flashes in breast cancer survivors, opening non-hormonal management pathways.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
关注 查尔斯·洛普林齐 的研究动态
Follow Charles Loprinzi's research updates
留下邮箱，当我们发布与 Charles Loprinzi（Mayo Clinic）相关的新研究或访谈时，我们会通知你。
Explore More Experts
Discover the researchers shaping the future of cancer treatment