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Translational Medicine / 转化医学FLASH Mechanism, Oxygen Depletion Biology

Charles Limoli

PhD

🏢University of California, Irvine🌐USA

Professor of Radiation Oncology

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Key Contributions

👥Biography 个人简介

Charles Limoli has been central to elucidating the biological mechanisms underlying the FLASH effect, investigating the roles of transient oxygen depletion, reactive oxygen species chemistry, and immune modulation. His work has shown that FLASH irradiation produces distinct patterns of DNA damage and inflammatory responses compared to conventional dose rates. He has provided critical insights into why FLASH preferentially spares normal tissue while maintaining tumor control.

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🧪Research Fields 研究领域

FLASH mechanism biology
oxygen depletion radiation
reactive oxygen species FLASH
radiation-induced inflammation
normal tissue radioprotection

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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