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Translational Medicine / 转化医学GIST Translational Research, SDH-Deficient GIST

Cesar Serrano

MD, PhD

🏢Vall d'Hebron Institute of Oncology (VHIO), Barcelona🌐Spain

Head, Sarcoma Translational Research Laboratory

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Key Contributions

👥Biography 个人简介

Dr. Cesar Serrano is a leading translational researcher focused on SDH-deficient GIST, a molecularly distinct subtype that lacks KIT/PDGFRA mutations and affects primarily younger patients. His laboratory has elucidated the biology of SDH complex mutations in GIST, including hypermethylation patterns and potential therapeutic vulnerabilities, opening new research directions for these currently imatinib-resistant tumors.

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🧪Research Fields 研究领域

SDH-deficient GIST biology
succinate dehydrogenase mutations
pediatric GIST
Carney triad
GIST epigenetics

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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