Céleste Lebbé
塞莱斯特·勒贝
MD, PhD
Professor of Dermatology; Head, Dermato-Oncology Unit皮肤病学教授；皮肤肿瘤科主任
👥Biography 个人简介
Céleste Lebbé, MD, PhD is Professor of Dermatology and Head of the Dermato-Oncology Unit at Hôpital Saint-Louis in Paris, and a leading European authority on basal cell carcinoma (BCC) and acral melanoma. She conducted pivotal research establishing cemiplimab as the first immunotherapy approved for advanced BCC after hedgehog pathway inhibitor (HHI) failure, and has led multiple French and European trials in rare cutaneous malignancies. Her translational program bridges genomic characterization and clinical trial design for understudied skin cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Cemiplimab After Hedgehog Inhibitor Failure in Advanced BCC
Led the EMPOWER-BCC 1 trial contribution establishing cemiplimab as effective immunotherapy for locally advanced and metastatic BCC that had progressed on or was intolerant to vismodegib/sonidegib, supporting the first immunotherapy approval in BCC.
Hedgehog Pathway Inhibitor Sequencing in BCC
Conducted clinical studies characterizing mechanisms of HHI resistance in advanced BCC and evaluating strategies for drug holidays and re-challenge, informing real-world management of this challenging rare tumor.
Acral Melanoma Genomics and Treatment
Led the French cohort of acral melanoma translational studies, characterizing KIT mutations, CDK4 amplification, and distinct immunological microenvironment features relevant to immunotherapy and targeted therapy selection.
Representative Works 代表性著作
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy (EMPOWER-BCC 1)
New England Journal of Medicine (2021)
Phase II study demonstrating 29% objective response rate with cemiplimab in HHI-refractory advanced BCC, supporting FDA approval and establishing immunotherapy as second-line standard of care.
Genomic and immune characterization of acral melanoma: distinct from UV-driven cutaneous melanoma
Journal of Investigative Dermatology (2020)
Comprehensive molecular analysis of acral melanoma identifying actionable alterations and characterizing the immunosuppressive tumor microenvironment that may explain limited immunotherapy benefit in this subtype.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-20 | All information from publicly available academic sources
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