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Translational Medicine / 转化医学ovarian cancer biology and novel therapeutics

Stephanie Gaillard

斯蒂芬妮·盖拉德

MD, PhD

🏢Johns Hopkins School of Medicine(约翰斯·霍普金斯大学医学院)🌐USA

Associate Professor of Gynecologic Oncology妇科肿瘤学副教授

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Key Papers
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Awards
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Key Contributions

👥Biography 个人简介

Stephanie Gaillard is a gynecologic oncologist and translational researcher at Johns Hopkins who focuses on early carcinogenesis in fallopian tube cancer and novel therapeutic strategies beyond PARP inhibitors for ovarian cancer. Her laboratory studies BRCA1/2-associated fallopian tube precursor lesions (STICs) as origins of high-grade serous ovarian cancer, and she leads clinical trials of CDK4/6 inhibitors and WEE1 inhibitors in recurrent ovarian cancer. Gaillard has contributed to NRG Oncology trials and is developing ctDNA-based early detection strategies for ovarian cancer in high-risk BRCA mutation carriers.

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🧪Research Fields 研究领域

fallopian tube carcinogenesis输卵管致癌
BRCA1/2 early ovarian cancerBRCA1/2早期卵巢癌
CDK4/6 inhibitors ovarian cancerCDK4/6抑制剂卵巢癌
Wee1 inhibitorsWee1抑制剂
early detection ovarian cancer卵巢癌早期检测

🎓Key Contributions 主要贡献

Fallopian Tube Carcinogenesis Research

Characterized STICs (serous tubal intraepithelial carcinomas) as precursors of high-grade serous ovarian cancer, advancing understanding of disease origins and identifying opportunities for interception in high-risk women.

Novel Cell Cycle Inhibitors in Ovarian Cancer

Led clinical trials of CDK4/6 and WEE1 inhibitors in platinum-resistant ovarian cancer, identifying biomarkers of response and rational combination strategies with DNA-damaging agents.

Representative Works 代表性著作

[1]

Clinical Activity of Adavosertib (WEE1 Inhibitor) in Combination with Olaparib in Recurrent Ovarian Cancer

Clinical Cancer Research (2020)

Phase I/II trial of WEE1 plus PARP inhibition in ovarian cancer.

[2]

STICs as Precursors of BRCA-Associated Ovarian Cancer

Gynecologic Oncology (2017)

Characterization of serous tubal intraepithelial carcinomas in BRCA carriers.

🏆Awards & Recognition 奖项与荣誉

🏆SGO Future Leader Award
🏆NIH K23 Career Development Award
🏆Johns Hopkins Institute for Clinical and Translational Research Award

📄Data Sources 数据来源

Last updated: 2026-01-15 | All information from publicly available academic sources

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